Glutethimide and enzyme induction.
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چکیده
منابع مشابه
Enzyme induction and serum and lipoprotein lipids: a study of glutethimide in normal subjects.
1. Serum and lipoprotein cholesterol and triglycerides were measured before, during and after the administration of glutethimide (500 mg daily) for 21 days to six healthy volunteer subjects. 2. Evidence of enzyme induction was provided by significant rises in D-glucaric acid excretion and antipyrine clearance. 3. Concentrations of total serum cholesterol, very-low-density-lipoprotein-, low-dens...
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The rate and extent of drug metabolism significantly influences drug effect. Enzyme induction by increasing the metabolism of drugs may result in important drug interactions. Other implications of enzyme induction include alterations in the metabolism of endogenous substrates, vitamins and activity of extrahepatic enzyme systems. Similarly a wide range of drugs may produce clinically significan...
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Thalidomide in its heyday commonly produced neuropathy. The chemical similarity of the frequently used sedative glutethimide (Doriden) to thalidomide prompted Fullerton and Kremer (1961) to say, 'It is interesting that similar toxic effects have not been reported in patients taking glutethimide . . .'. Since this statement, three authors have reported a total of four cases of nervous system dam...
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Sir,—Thank you for the opportunity of replying to the letter from Drs Bradshaw and Maddison. We can assume only that these workers have been unable to confirm our observations because of some fundamental difference in technique. The difference is not immediately apparent from the information provided in their letter, but several possibilities exist. First, our patients, who were not premedicate...
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for it was largely intra-thoracic and yet the tear was limited to the oesophago-gastric junction. It is suggested here that there is occasionally a failure of relaxation of the lower oesophagus which raises the pressure gradient to a sufficient degree to cause a tear, for the lower oesophagus normally relaxes during vomiting and in this patient the gastrografin swallow showed evidence of abnorm...
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ژورنال
عنوان ژورنال: BMJ
سال: 1976
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.6046.1256-d